A first-of-its-kind Lifestyle Bioscreen

Biological storytelling that sharpens the decision.

CellWise reads single-cell gene expression and turns it into a story a clinician can act on: what's driving the symptoms a standard panel can't see, which systems are involved, and the exact next step.

✓ Founding pilot rate: $1,485 a patient ✓ Founder pricing ✓ No repeat sequencing to keep using it
CellWise · Donor 0412 · Cardiovascular
The signal
OLR1Z +5.93ABCA1Z +3.94VEGFAZ +3.74
CD14+ monocytes
What it means
A foam cell formation signature. Lipid handling stress inside the monocyte itself, not just in the serum.
The decision
Order ApoB, Lp(a), oxidized LDL and CIMT.
Why nothing else caught it
The standard lipid panel reads normal. In an asymptomatic patient, none of this would have been prioritized.
The signal
PPARGZ +3.90INSRZ +3.19TCF7L2Z +3.08
Monocyte populations
What it means
Insulin resistance that is monocyte driven, which points at inflammatory coupling rather than adipose dysfunction alone.
The decision
GLP-1 candidacy. Deploy CGM, order fasting insulin and HOMA-IR.
Why nothing else caught it
A metabolic panel would call this patient normal. Cell-type resolution is what makes the case early.
The signal
BMAL1Z +3.02CLOCKZ +2.63
NK cells and monocytes
What it means
Molecular evidence of circadian disruption in the immune compartment, upstream of the metabolic and inflammatory findings.
The decision
Anchor the sleep conversation in data, then re-screen after intervention.
Why nothing else caught it
There is no blood test for this. It is the difference between vague sleep hygiene advice and a root cause.
The signal
CD86Z +3.73CTLA4Z +2.52BAFFZ +1.68
Regulatory T cells
What it means
A checkpoint and B-cell activation pattern that precedes antibody positivity.
The decision
ANA, anti-dsDNA and RF if there are any joint symptoms.
Why nothing else caught it
These are tests you would normally defer in a healthy patient. This is the reason not to.
Grounded inreal population datapeer-reviewed researchlegacy single-cell technology
The Founding Practitioner Pilot: up to five of your own patients at $1,485 each for Core Plus, 29% below standard, invoiced only for the ones you send.
See the terms
One draw, one screen

Every system, read at the level of a single cell.

One PBMC sample resolves 400+ biomarker genes across immune cell populations, scored into the risk-rated health domains that shape how a patient feels and functions, the signal a standard panel averages away.

Inflammatory StressImmune & AutoimmuneMetabolicCardiovascularFertility & ReproductiveFitness & PerformanceToxicityEarly Disease Predictors
Wireframe human figure with the major body systems lit up as connected nodes
What carries the product

A Lifestyle Bioscreen, built for action.

CellWise organizes single-cell analysis around the health categories that shape how a patient actually feels and functions, and resolves the drivers a standard panel can't see.

Not just that a marker is high, but which cell populations are driving it, so the source is visible and addressable.

Glycolytic versus oxidative efficiency across immune cell types, the axis that anticipates how a patient responds to therapy.

Early cardiometabolic risk read from immune and metabolic signals, before it surfaces on a standard workup.

Th1 skew, NK cytotoxicity, and IFNG context that meaningfully informs a reproductive-immunology conversation.

Biological storytelling, in action

Depth that changes the next step.

Three examples of the reasoning CellWise surfaces, and the decision each one sharpens.

Autoimmune triage
Unexplained fatigue and joint pain. The standard panel reads normal.

CellWise converges TLR9, IRF7, and TLR7 in plasmacytoid dendritic cells with IFNG in NK cells into a single coherent interferonopathy signature.

→ Focuses the workup on ANA, anti-dsDNA, complement, and EBV/CMV serology, not a broad metabolic screen
Peptide guardrails
A patient on a GHRH analog, with immune hyperactivation.

The platform flags Sermorelin and Tesamorelin as use-with-caution in that immune context, and rates GLP-1 agonists optimal with an explicit monocyte-targeting rationale.

→ A prescribing pause you'd want to make before the next cycle
Fertility specificity
A reproductive-health conversation with no clear immune picture.

A Th1 skew, elevated NK cytotoxicity, and IFNG elevation give the immune context behind the presentation.

→ Meaningfully informs the referral to a reproductive immunologist

◆ Illustrative reads from simulated beta review, shown to demonstrate the platform's reasoning. Not from a specific patient.

Everything in the portal

Seven modules, one clinical workspace.

Health Analysis Report

The clinical home base. Use-case assessments, immuno-metabolic phenotyping, the therapeutic target map, stress profiling, and more, all in one report.

Biomarker Analytics

The quantitative, visual view of the patient's raw biomarker data, shown as a population-vs-patient overview.

Data Explorer

A filterable, gene-level interface over the patient's complete dataset, exposing the top cell populations carrying each signal.

Clinical Scenario Simulator

Test a clinical hypothesis against the patient's own molecular data and re-run it in seconds.

Outcomes & Monitoring

Assay-independent surveillance across dosing phases, peptide-specific labs, and wearable trends, with no repeat sequence required.

Cellular Aging Profile

Immune age, senescence, and the 12 hallmarks from one PBMC sample, for cell-resolved biological aging.

Δ

Longitudinal Screening

Re-assay a patient and see the gene-expression deltas across key biomarkers, so you see what has shifted since the last screen.

Who it's for

Built for the practices that read molecular data.

Pick the workspace tuned to how your practice actually prescribes, tracks, and bills.

What the beta measured

Reviewers put numbers to the value.

Three independent reviewers read the same donor in isolation, and converged on the same labs, the same contraindication, and the same candidacy call.

45→15 min
Chart prep on a complex patient, with 4–5 hours of clinical time recovered each week at 8–10 such patients.
$3–5k
Downstream testing avoided per complex patient by front-loading the mechanistic picture instead of iterating toward it.
21 days
From sample receipt at the sequencing lab to a finished report in the practitioner portal.
≥1
Contraindicated peptide prevented per complex patient, like GHRH analogs withheld in a hyper-inflammatory state.
2–3 hrs
Of practitioner synthesis replaced, a full literature review connecting expression to hypothesis to intervention.
8–12
Additional targeted lab orders surfaced that a standard annual panel would never have generated.
From the review room

What the reviewers kept coming back to.

It reads like a narrative, not a spreadsheet. The mechanism, the systems involved, and the next step arrive in one card, instead of an afternoon spent interpreting gene lists myself.

Concierge Longevity MD
Beta review

What sets it apart is that every finding comes with a decision attached: the specific lab to order or the compound to reconsider, not just another number to sit with.

Integrative Medicine NMD
Beta review

A conventional panel reads normal while the patient is still symptomatic. CellWise resolves which cells are dysregulated and why, which is a different level of resolution than anything I can order today.

Functional Medicine MD
Beta review
◆ Illustrative, not testimonial. These show the kind of read the report supports, drafted from clinician personas during beta design rather than quoted from named practitioners. Reviews from the founding pilot will replace them.

Baseline up to five patients, at the founding rate.

Join the founding pilot: up to five of your own patients at $1,485 each, 29% below the standard rate, invoiced only for the ones you send. Founding rates lock for twelve months if you go forward, and every pilot practice is a design partner with a say on what gets built. Open to the first fifty founding practices.